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Article

Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures

11 Nov 2019

Abstract excerpt

Sporadic colorectal cancer (CRC) is a result of complex interactions between the host and its environment. Environmental stressors act by causing host cell DNA alterations implicated in the onset of cancer. Here we investigate the stressor ability of CRC-associated gut dysbiosis as causal agent of host DNA alterations. The epigenetic nature of these alterations was investigated in humans and in mice. Germ-free...

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PMID: 31712445
DOI: 10.1073/pnas.1912129116

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