Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.

doi:10.1101/gr.247882.118

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Article

Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.

Genome research - 1 Dec 2019

Alriyami Maha, Marchand Luc, Li Quan, Du Xiaoyu, Olivier Martin, Polychronakos Constantin

Abstract excerpt

Concordance for type 1 diabetes (T1D) is far from 100% in monozygotic twins and in inbred nonobese diabetic (NOD) mice, despite genetic identity and shared environment during incidence peak years. This points to stochastic determinants, such as postzygotic mutations (PZMs) in the expanding antigen-specific autoreactive T cell lineages, by analogy to their role in the expanding tumor lineage in cancer. Using...

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Identifiers

PMID: 31694869
DOI: 10.1101/gr.247882.118
PMCID: PMC6886509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.