Effect of (R)-salbutamol on the switch of phenotype and metabolic pattern in LPS-induced macrophage cells.

doi:10.1111/jcmm.14780

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Article

Effect of (R)-salbutamol on the switch of phenotype and metabolic pattern in LPS-induced macrophage cells.

Journal of cellular and molecular medicine - 1 Jan 2020

Wang Shanping, Liu Fei, Tan Keai Sinn, Ser Hooi-Leng, Tan Loh Teng-Hern, Lee Learn-Han, Tan Wen

Abstract excerpt

Evidence demonstrates that M1 macrophage polarization promotes inflammatory disease. Here, we discovered that (R)-salbutamol, a β2 receptor agonist, inhibits and reprograms the cellular metabolism of RAW264.7 macrophages. (R)-salbutamol significantly inhibited LPS-induced M1 macrophage polarization and downregulated expressions of typical M1 macrophage cytokines, including monocyte chemotactic protein-1 (MCP-1),...

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Identifiers

PMID: 31680470
DOI: 10.1111/jcmm.14780
PMCID: PMC6933346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.