Article
Interleukin-18 and outcome after allogeneic stem cell transplantation: A retrospective cohort study.
EBioMedicine - 1 Nov 2019
Radujkovic Aleksandar, Kordelas Lambros, Dai Hao, Schult David, Majer-Lauterbach Joshua, Beelen Dietrich, Müller-Tidow Carsten, Dreger Peter, Luft Thomas
Abstract excerpt
BACKGROUND: Interleukin-18 (IL-18) is involved in endothelial activation and dysfunction, and in the pathogenesis and severity of acute graft-versus-host disease (aGVHD). Its relevance for patient outcome after allogeneic stem cell transplantation (alloSCT) has not yet been comprehensively addressed. METHODS: Pre-transplant serum levels of free IL-18 were retrospectively assessed in a cohort of 589 patients...
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