Regulation of Numb during planar cell polarity establishment in the Drosophila eye.

doi:10.1016/j.mod.2019.103583

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Article

Regulation of Numb during planar cell polarity establishment in the Drosophila eye.

Mechanisms of development - 1 Dec 2019

Domingos Pedro M, Jenny Andreas, Combie Keon F, Del Alamo David, Mlodzik Marek, Steller Hermann, Mollereau Bertrand

Abstract excerpt

The establishment of planar cell polarity (PCP) in the Drosophila eye requires correct specification of the R3/R4 pair of photoreceptor cells, determined by a Frizzled mediated signaling event that specifies R3 and induces Delta to activate Notch signaling in the neighboring cell, specifying it as R4. Here, we investigated the role of the Notch signaling negative regulator Numb in the specification of R3/R4 fates...

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Identifiers

PMID: 31678471
DOI: 10.1016/j.mod.2019.103583
PMCID: PMC6980312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.