Carboxylated nanodiamond-mediated CRISPR-Cas9 delivery of human retinoschisis mutation into human iPSCs and mouse retina.

doi:10.1016/j.actbio.2019.10.037

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Carboxylated nanodiamond-mediated CRISPR-Cas9 delivery of human retinoschisis mutation into human iPSCs and mouse retina.

Acta biomaterialia - 1 Jan 2020

Yang Tien-Chun, Chang Chia-Yu, Yarmishyn Aliaksandr A, Mao Yen-Shiang, Yang Yi-Ping, Wang Mong-Lien, Hsu Chih-Chien, Yang Hsin-Yu, Hwang De-Kuang, Chen Shih-Jen, Tsai Ming-Long, Lai Yun-Hsien, Tzeng Yonhua, Chang Chia-Ching, Chiou Shih-Hwa

Abstract excerpt

Nanodiamonds (NDs) are considered to be relatively safe carbon nanomaterials used for the transmission of DNA, proteins and drugs. The feasibility of utilizing the NDs to deliver CRISPR-Cas9 system for gene editing has not been clearly studied. Therefore, in this study, we aimed to use NDs as the carriers of CRISPR-Cas9 components designed to introduce the mutation in RS1 gene associated with X-linked...

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Identifiers

PMID: 31672582
DOI: 10.1016/j.actbio.2019.10.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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