Aurora kinase A-mediated phosphorylation of mPOU at a specific site drives skeletal muscle differentiation.

doi:10.1093/jb/mvz088

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Article

Aurora kinase A-mediated phosphorylation of mPOU at a specific site drives skeletal muscle differentiation.

Journal of biochemistry - 1 Feb 2020

Karthigeyan Dhanasekan, Bose Arnab, Boopathi Ramachandran, Rao Vinay Jaya, Shima Hiroki, Bharathy Narendra, Igarashi Kazuhiko, Taneja Reshma, Trivedi Arun Kumar, Kundu Tapas K

Abstract excerpt

Aurora kinases are Ser/Thr-directed protein kinases which play pivotal roles in mitosis. Recent evidences highlight the importance of these kinases in multiple biological events including skeletal muscle differentiation. Our earlier study identified the transcription factor POU6F1 (or mPOU) as a novel Aurora kinase (Aurk) A substrate. Here, we report that Aurora kinase A phosphorylates mPOU at Ser197 and inhibit...

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Identifiers

PMID: 31665313
DOI: 10.1093/jb/mvz088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.