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Article

Mutation in cyp51A and high expression of efflux pump gene of Aspergillus fumigatus induced by propiconazole in liquid medium and soil.

Environmental pollution (Barking, Essex : 1987) - 1 Jan 2020

Cao Duantao, Yao Shijie, Zhang Hongchao, Wang Saige, Jin Xiangxiang, Lin Dunli, Fang Hua, Yu Yunlong

Abstract excerpt

Triazole resistance in Aspergillus fumigatus is a major cause of clinical inefficacy in the treatment of invasive aspergillosis (IA). The hypothesis that triazole fungicides have driven the development of resistance in A. fumigatus has garnered substantial attention due to the similar structure and global detection of antifungal resistant A. fumigatus (ARAF) isolates in the soil. However, there is little evidence...

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PMID: 31662261
DOI: 10.1016/j.envpol.2019.113385

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