Nucleotide excision repair genes shaping embryonic development.

doi:10.1098/rsob.190166

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Article

Nucleotide excision repair genes shaping embryonic development.

Open biology - 31 Oct 2019

Araújo Sofia J, Kuraoka Isao

Abstract excerpt

Nucleotide excision repair (NER) is a highly conserved mechanism to remove helix-distorting DNA lesions. A major substrate for NER is DNA damage caused by environmental genotoxins, most notably ultraviolet radiation. Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy are three human disorders caused by inherited defects in NER. The symptoms and severity of these diseases vary dramatically, ranging...

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PMID: 31662099
DOI: 10.1098/rsob.190166
PMCID: PMC6833223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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