Article
Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine.
Molecular therapy : the journal of the American Society of Gene Therapy - 4 Dec 2019
Sariyer Ilker Kudret, Gordon Jennifer, Burdo Tricia H, Wollebo Hassen S, Gianti Eleonora, Donadoni Martina, Bellizzi Anna, Cicalese Stephanie, Loomis Regina, Robinson Jake A, Carnevale Vincenzo, Steiner Joseph, Ozdener Mehmet H, Miller Andrew D, Amini Shohreh, Klein Michael L, Khalili Kamel
Abstract excerpt
Zika virus (ZIKV) infection is associated with microcephaly in neonates and Guillain-Barré syndrome in adults. ZIKV produces a class of nonstructural (NS) regulatory proteins that play a critical role in viral transcription and replication, including NS5, which possesses RNA-dependent RNA polymerase (RdRp) activity. Here we demonstrate that rilpivirine (RPV), a non-nucleoside reverse transcriptase inhibitor...
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