SNAIL- and SLUG-induced side population phenotype of HCT116 human colorectal cancer cells and its regulation by BET inhibitors.

doi:10.1016/j.bbrc.2019.10.094

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Article

SNAIL- and SLUG-induced side population phenotype of HCT116 human colorectal cancer cells and its regulation by BET inhibitors.

Biochemical and biophysical research communications - 1 Jan 2020

Kato Yu, Kondo Shingo, Itakura Taira, Tokunaga Miku, Hatayama Shiori, Katayama Kazuhiro, Sugimoto Yoshikazu

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is associated with cancer malignancies such as invasion, metastasis, and drug resistance. In this study, HCT116 human colorectal cancer cells were transduced with SLUG or SNAIL retroviruses, and EMT cells with mesenchymal morphology were established. The EMT cells showed a high invasive activity and resistance to several anticancer agents such as methotrexate, SN-38, and...

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PMID: 31653342
DOI: 10.1016/j.bbrc.2019.10.094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.