Cardiac Pacemaker Cells Generate Cardiomyocytes from Fibroblasts in Long-Term Cultures.

doi:10.1038/s41598-019-51001-6

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Article

Cardiac Pacemaker Cells Generate Cardiomyocytes from Fibroblasts in Long-Term Cultures.

Scientific reports - 23 Oct 2019

Kiuchi Shigeki, Usami Akino, Shimoyama Tae, Otsuka Fuminori, Yamaguchi Sachiko, Nakamura Tomonori, Suzuki Shigeto, Ono Kageyoshi

Abstract excerpt

Because cardiomyocyte generation is limited, the turnover of cardiomyocytes in adult heart tissues is much debated. We report here that cardiac pacemaker cells can generate cardiomyocytes from fibroblasts in vitro. Sinoatrial node cells (SANCs) were isolated from adult guinea pig hearts and were cultured at relatively low cell densities. Within a week, a number of fibroblast-like cells were observed to gather...

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Identifiers

PMID: 31645588
DOI: 10.1038/s41598-019-51001-6
PMCID: PMC6811548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.