Energetics of Flap Opening in HIV-1 Protease: String Method Calculations.

doi:10.1021/acs.jpcb.9b08348

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Article

Energetics of Flap Opening in HIV-1 Protease: String Method Calculations.

The journal of physical chemistry. B - 14 Nov 2019

Gardner Jasmine M, Abrams Cameron F

Abstract excerpt

HIV-1 protease (PR) is the viral protein responsible for virion maturation, and its mechanisms of action remain incompletely understood. PR is dimeric and contains two flexible, symmetry-related flaps, which act as a gate to inhibit access to the binding pocket and hold the polypeptide substrate in the binding pocket once bound. Wide flap opening, a conformational change assumed to be necessary for substrate...

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Identifiers

PMID: 31640343
DOI: 10.1021/acs.jpcb.9b08348
PMCID: PMC7375464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.