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DMPK gene DNA methylation levels are associated with muscular and respiratory profiles in DM1

24 May 2019

Abstract excerpt

OBJECTIVE: ) DNA methylation (DNAme) epivariation on muscular and respiratory profiles in patients with myotonic dystrophy type 1 (DM1). METHODS: Phenotypes were assessed with standardized measures. Pyrosequencing of bisulfite-treated DNA was used to quantify DNAme levels in blood from 90 patients with DM1 (adult form). Modal CTG repeat length was assessed using small-pool PCR. The presence of Acil-sensitive...

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PMID: 31334355
DOI: 10.1212/nxg.0000000000000338

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DMPK gene DNA methylation levels are associated with muscular and respiratory profiles in DM1PMID 31334355Read ↗

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