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Antisense therapies for movement disorders

8 Jul 2019

Abstract excerpt

Currently, few disease-modifying therapies exist for degenerative movement disorders. Antisense oligonucleotides are small DNA oligonucleotides, usually encompassing ∼20 base pairs, that can potentially target any messenger RNA of interest. Antisense oligonucleotides often contain modifications to the phosphate backbone, the sugar moiety, and the nucleotide base. The development of antisense oligonucleotide...

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PMID: 31283857
DOI: 10.1002/mds.27782

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