Exome-Based Rare-Variant Analyses in CKD

Abstract excerpt

Significance Statement Studies have identified common CKD-associated gene variants, but the contribution of rare variants has not been systematically examined. The authors use exome sequencing and rare-variant collapsing analyses to compare rare genetic variants in 3150 cases (representing broad clinical CKD subtypes) with 9563 controls. For five known CKD-associated genes, they detected a significant enrichment...

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