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Impact of Genes and the Environment on the Pathogenesis and Disease Course of Inflammatory Bowel Disease.

Digestive diseases and sciences - 1 Jul 2019

Zhao Mirabella, Burisch Johan

Abstract excerpt

Crohn's disease and ulcerative colitis constitute two major subgroups of inflammatory bowel diseases (IBD), a group of complex polygenic diseases characterized by chronic and progressive inflammation in the gastrointestinal tract. In recent years, methodological advances in genetic analysis have greatly expanded our understanding of the genetic background of IBD. So far, more than 240 genetic risk loci have been...

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PMID: 31073736
DOI: 10.1007/s10620-019-05648-w

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