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Nontuberculous Mycobacteria Persistence in a Cell Model Mimicking Alveolar Macrophages

26 Apr 2019

Abstract excerpt

Nontuberculous Mycobacteria (NTM) respiratory infections have been gradually increasing. Here, THP-1 cells were used as a model to evaluate intracellular persistence of three NTM species (reference and clinical strains) in human alveolar macrophages. The contribution of phagosome acidification, nitric oxide (NO) production and cell dead on NTM intracellular fate was assessed. In addition, strains were...

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PMID: 31035520
DOI: 10.3390/microorganisms7050113

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