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Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients

16 Apr 2019

Abstract excerpt

BACKGROUND: It is well known that human clear cell renal cell carcinoma (ccRCC) is a highly immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune checkpoint blockade therapy is an important breakthrough in the treatment against ccRCC. HHLA2, a recently reported member of B7 family, is uniquely expressed in humans but not in mice, and it plays an important role in the functional...

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PMID: 31015801
DOI: 10.1186/s12935-019-0813-2

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