Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Schwann cell transcript biomarkers for hereditary neuropathy skin biopsies

4 Apr 2019

Abstract excerpt

OBJECTIVE: Charcot-Marie-Tooth (CMT) disease is most commonly caused by duplication of a chromosomal segment surrounding Peripheral Myelin Protein 22, or PMP22 gene, which is classified as CMT1A. Several candidate therapies reduce Pmp22 mRNA levels in CMT1A rodent models, but development of biomarkers for clinical trials in CMT1A is a challenge given its slow progression and difficulty in obtaining nerve samples....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hereditary Neurological Disorders
Share to Nerve injury and regeneration
Share to Peripheral Neuropathies and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30945774
DOI: 10.1002/ana.25480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Schwann cell transcript biomarkers for hereditary neuropathy skin biopsiesPMID 30945774Read ↗

PMP22 expression in dermal nerve myelin from patients with CMT1ASemantic proximity Read ↗

Long term AAV2/9-mediated silencing of PMP22 prevents CMT1A disease in rats and validates skin biomarkers as treatment outcome measureSemantic proximity Read ↗

CMT1A current gene therapy approaches and promising biomarkersSemantic proximity Read ↗

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent modelsSemantic proximity Read ↗

Circulating transcriptional biomarkers serve as surrogates of disease progression in Charcot-Marie-Tooth 1A diseaseSemantic proximity Read ↗

AAV2/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1 ASemantic proximity Read ↗

Elevated Peripheral Myelin Protein 22, Reduced Mitotic Potential, and Proteasome Impairment in Dermal Fibroblasts from Charcot-Marie-Tooth Disease Type 1A PatientsSemantic proximity Read ↗

MicroRNAs as Biomarkers of Charcot-Marie-Tooth Disease Type 1ASemantic proximity Read ↗

PMP22 messenger RNA levels in skin biopsies: testing the effectiveness of a Charcot-Marie-Tooth 1A biomarkerSemantic proximity Read ↗

A study concept of expeditious clinical enrollment for genetic modifier studies in Charcot-Marie-Tooth neuropathy 1A.Semantic proximity Read ↗

Transcriptomic profiling of human skin biopsies in the clinical trial setting: A protocol for high quality RNA extraction from skin tumoursSemantic proximity Read ↗

PMP22-Related neuropathies and other clinical manifestations in Chinese han patients with charcot-marie-tooth disease type 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.