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Mice Against Ticks: an experimental community-guided effort to prevent tick-borne disease by altering the shared environment

25 Mar 2019

Abstract excerpt

Mice Against Ticks is a community-guided ecological engineering project that aims to prevent tick-borne disease by using CRISPR-based genome editing to heritably immunize the white-footed mice ( Peromyscus leucopus) responsible for infecting many ticks in eastern North America. Introducing antibody-encoding resistance alleles into the local mouse population is anticipated to disrupt the disease transmission cycle...

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PMID: 30905296
DOI: 10.1098/rstb.2018.0105

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