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Crucial Role of Microbiota in Experimental Psoriasis Revealed by a Gnotobiotic Mouse Model

21 Feb 2019

Abstract excerpt

Psoriatic patients have altered microbiota, both in the intestine and on the skin. It is not clear, however, whether this is a cause or consequence of the disease. In this study using an experimental mouse model of psoriasis induced by imiquimod, we show that oral treatment with a broad spectrum of antibiotics (ATB) or metronidazole (MET) alone mitigates the severity of skin inflammation through downregulation of...

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PMID: 30846974
DOI: 10.3389/fmicb.2019.00236

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