Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells.

doi:10.1002/stem.2996

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Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells.

Stem cells (Dayton, Ohio) - 1 Jun 2019

Liu Senquan, Mahairaki Vasiliki, Bai Hao, Ding Zheng, Li Jiaxin, Witwer Kenneth W, Cheng Linzhao

Abstract excerpt

Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communications and exert various biological activities via delivering unique cargos of functional molecules such as RNAs and proteins to recipient cells. Previous studies showed that EVs produced and secreted by human mesenchymal stem cells (MSCs) can substitute intact MSCs for tissue repair and regeneration. In this study,...

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PMID: 30811771
DOI: 10.1002/stem.2996
PMCID: PMC6767364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.