Article
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Human molecular genetics - 1 Jul 2019
Baron Desiree M, Matheny Tyler, Lin Yen-Chen, Leszyk John D, Kenna Kevin, Gall Katherine V, Santos David P, Tischbein Maeve, Funes Salome, Hayward Lawrence J, Kiskinis Evangelos, Landers John E, Parker Roy, Shaffer Scott A, Bosco Daryl A
Abstract excerpt
Aberrant translational repression is a feature of multiple neurodegenerative diseases. The association between disease-linked proteins and stress granules further implicates impaired stress responses in neurodegeneration. However, our knowledge of the proteins that evade translational repression is incomplete. It is also unclear whether disease-linked proteins influence the proteome under conditions of...
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