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Article

Reverse signaling via PD-L1 supports malignant cell growth and survival in classical Hodgkin lymphoma

19 Feb 2019

Abstract excerpt

Treatment with programmed death-1 (PD-1) blocking antibodies results in high overall response rates in refractory and relapsed classical Hodgkin lymphoma (cHL) patients, indicating that PD-1/PD-1 ligand interactions are integral to progression of this disease. Given the genetically driven increased PD-L1/2 expression in HL, we hypothesized that reverse signaling through PD-1 ligands may be a potential mechanism...

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PMID: 30783096
DOI: 10.1038/s41408-019-0185-9

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