Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability

Abstract excerpt

Significance Heart failure is the leading cause of death worldwide. Cardiac regeneration studies currently focus on zebrafish, urodeles, and mammals, bypassing the amphibian Xenopus laevis , despite being considered as a leading model for regeneration research. We thus took advantage of X. laevis as a model to explore thyroid hormone (TH) influence on the cardiac regenerative process. We suggest a possible link...

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