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Article

Metastable asymmetrical structure of a shaftless V1 motor.

Science advances - 1 Jan 2019

Maruyama Shintaro, Suzuki Kano, Imamura Motonori, Sasaki Hikaru, Matsunami Hideyuki, Mizutani Kenji, Saito Yasuko, Imai Fabiana L, Ishizuka-Katsura Yoshiko, Kimura-Someya Tomomi, Shirouzu Mikako, Uchihashi Takayuki, Ando Toshio, Yamato Ichiro, Murata Takeshi

Abstract excerpt

V1-ATPase is an ATP-driven rotary motor that is composed of a ring-shaped A3B3 complex and a central DF shaft. The nucleotide-free A3B3 complex of Enterococcus hirae, composed of three identical A1B1 heterodimers, showed a unique asymmetrical structure, probably due to the strong binding of the N-terminal barrel domain, which forms a crown structure. Here, we mutated the barrel region to weaken the crown, and...

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Identifiers

PMID: 30729160
DOI: 10.1126/sciadv.aau8149
PMCID: PMC6353620

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Source receipt: pubmed, retrieved 7 Sept 2026.

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