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Methylation levels ofIGF2andKCNQ1in spermatozoa from infertile men are associated with sperm DNA damage

24 Jan 2019

Abstract excerpt

Abnormal imprinted genes methylation in spermatozoa has been shown to be associated with subfertility. However, the relationship between sperm DNA damage and specific imprinted genes methylation remains unclear. In this study, DNA methylation levels were determined at seven imprinted genes loci (H19, INS-IGF2, KCNQ1, MEG3, MEST, PEG3 and SNRPN) in 66 semen samples using the MSRE-qPCR method. The semen samples...

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Share to Epigenetics and DNA Methylation
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PMID: 30680773
DOI: 10.1111/and.13239

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