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Article

Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients

17 Jan 2019

Abstract excerpt

Significance Statement Case reports describe scenarios in which previously undiagnosed genetic disorders, such as primary hyperoxaluria type 1, caused early allograft failure in kidney transplant recipients. Whole-exome sequencing (WES) has found that approximately 20% of pediatric patients with CKD have a relevant mutation, but the diagnostic yield of WES in kidney transplant recipients is not known. In this...

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Share to Genetic and Kidney Cyst Diseases
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PMID: 30655312
DOI: 10.1681/asn.2018060575

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