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Article

The relationship among sperm global DNA methylation, telomere length, and DNA fragmentation in varicocele: a cross-sectional study of 20 cases

2 Jan 2019

Abstract excerpt

Varicocele pathophysiology is related to increased oxidative stress, which might result in loss sperm DNA integrity as well as in genomic instability. Sperm telomere shortening and loss of global DNA methylation are the main features of genomic instability, leading to cell senescence and death, whereas sperm DNA fragmentation (SDF) characterizes the loss of chromatin integrity. We hypothesize that sperm genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30601031
DOI: 10.1080/19396368.2018.1557762

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