Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of miR‐146b‐5p promotes T cell acute lymphoblastic leukemia migration and invasion via the IL‐17A pathway

25 Oct 2018

Abstract excerpt

Abstract Metastatic disease remains the primary cause of death for individuals with T cell acute lymphoblastic leukemia (T‐ALL). microRNAs (miRNAs) play important roles in the pathogenesis of T‐ALL by inhibiting gene expression at posttranscriptional levels. The goal of the current project is to identify any significant miRNAs in T‐ALL metastasis. We observed miR‐146b‐5p to be downregulated in T‐ALL patients and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Cytokine Signaling Pathways and Interactions
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30362152
DOI: 10.1002/jcb.27882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of miR‐146b‐5p promotes T cell acute lymphoblastic leukemia migration and invasion via the IL‐17A pathwayPMID 30362152Read ↗

MicroRNA expression and activity in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansionSemantic proximity Read ↗

A tumor suppressor role of the miR-15b/16-2 cluster in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5pSemantic proximity Read ↗

IL ‐17A promotes cell migration and invasion of glioblastoma cells via activation of PI 3K/ AKT signalling pathwaySemantic proximity Read ↗

miR-17-92 expression in differentiated T cells - implications for cancer immunotherapySemantic proximity Read ↗

MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

A functional polymorphism in the miR-146a gene is associated with the risk of childhood acute lymphoblastic leukemia: a preliminary report.Semantic proximity Read ↗

Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphomaSemantic proximity Read ↗

STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer PhenotypesSemantic proximity Read ↗

Identification of a miR-146b-Fas ligand axis in the development of neutropenia in T large granular lymphocyte leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.