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Article

Phage-Antibiotic Synergy via Delayed Lysis

12 Sept 2018

Abstract excerpt

Phage-antibiotic synergy (PAS) has been reported for a decade, but the underlying mechanism has never been vigorously investigated. This study shows the presence of PAS from a variety of phage-bacterium-antibiotic pairings. We show that increased phage production resulted directly from a lysis delay caused by the relative shortage of holin in filamented bacterial hosts in the presence of sublethal concentrations...

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PMID: 30217844
DOI: 10.1128/aem.02085-18

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