Article
Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.
Scientific reports - 12 Sept 2018
Munz Matthias, Richter Gesa M, Loos Bruno G, Jepsen Søren, Divaris Kimon, Offenbacher Steven, Teumer Alexander, Holtfreter Birte, Kocher Thomas, Bruckmann Corinna, Jockel-Schneider Yvonne, Graetz Christian, Munoz Loreto, Bhandari Anita, Tennstedt Stephanie, Staufenbiel Ingmar, van der Velde Nathalie, Uitterlinden André G, de Groot Lisette C P G M, Wellmann Jürgen, Berger Klaus, Krone Bastian, Hoffmann Per, Laudes Matthias, Lieb Wolfgang, Franke Andre, Dommisch Henrik, Erdmann Jeanette, Schaefer Arne S
Abstract excerpt
Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD...
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