Non-neutralizing antibodies increase endogenous circulating Ang1 levels.

doi:10.1080/19420862.2018.1521130

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Article

Non-neutralizing antibodies increase endogenous circulating Ang1 levels.

mAbs - 1 Jan 2000

Zheng Chao, Toth Joshuaine, Bigwarfe Tammy, MacDougall Margit, Jerath Kavita, Bovat Kristin, Smith James, Sun Peng, Hayes David, Fryer Ryan, Singh Sanjaya, Kroe-Barrett Rachel

Abstract excerpt

Ang1 is a soluble ligand to receptor Tie2, and increasing the circulating Ang1 level may improve vascular stabilization under certain disease conditions. Here, we found that the circulating Ang1 level was significantly increased in cynomolgus monkeys treated with non-neutralizing anti-Ang1 antibodies. Improving the antibodies' pharmacokinetic properties by IgG Fc mutations further increased the circulating Ang1...

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Share to Angiopoietin-1
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Identifiers

PMID: 30199300
DOI: 10.1080/19420862.2018.1521130
PMCID: PMC6284558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.