Article
Targeting epigenetic mechanisms in periodontal diseases.
Periodontology 2000 - 1 Oct 2018
Barros Silvana P, Hefni Eman, Nepomuceno Rafael, Offenbacher Steven, North Kari
Abstract excerpt
Epigenetic factors are heritable genome modifications that potentially impact gene transcription, contributing to disease states. Epigenetic marks play an important role in chronic inflammatory conditions, as observed in periodontal diseases, by allowing microbial persistence or by permitting microbial insult to play a role in the so-called 'hit-and-run' infectious mechanism, leading to lasting pathogen...
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