Article
PDCB does not promote CNS autoimmunity in the context of genetic susceptibility but worsens its outcome.
Journal of neuroimmunology - 15 Oct 2018
Dubey Divyanshu, Hussain Rehana Z, Miller-Little William A, Salter Amber, Doelger Richard, Stüve Olaf
Abstract excerpt
BACKGROUND: Para-dichlorobenzene (PDCB) is an aromatic hydrocarbon contained in mothballs that is potentially neurotoxic. A potential pathogenic role of PDCB in MS pathogenesis has been suggested. METHODS: To determine the ability of chronic PDCB ingestion to induce CNS autoimmunity in a genetically susceptible mammalian species, naive myelin oligodendrocyte glycoprotein peptide (MOGp)35-55 T cell receptor (TCR)...
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