Extracellular ubiquitin modulates cardiac fibroblast phenotype and function via its interaction with CXCR4.

doi:10.1016/j.lfs.2018.09.012

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Article

Extracellular ubiquitin modulates cardiac fibroblast phenotype and function via its interaction with CXCR4.

Life sciences - 15 Oct 2018

Scofield Stephanie L C, Daniels Christopher R, Dalal Suman, Millard Jonathan A, Singh Mahipal, Singh Krishna

Abstract excerpt

AIMS: β-adrenergic receptor (β-AR) stimulation increases extracellular levels of ubiquitin (UB), and exogenous UB plays an important role in β-AR-stimulated myocardial remodeling with effects on heart function, fibrosis and myocyte apoptosis. Cardiac fibroblasts are vital for maintaining the normal function of the heart, and in the structural remodeling of the heart in response to injury. Here we hypothesized...

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Identifiers

PMID: 30195032
DOI: 10.1016/j.lfs.2018.09.012
PMCID: PMC6173983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.