Article
[Significance of somatic mutations on the prognosis of myelodysplastic syndromes].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2000
Yoshizato Tetsuichi
Abstract excerpt
During the past decade, substantial advances have been made in our understanding of the genetic basis of myelodysplastic syndromes (MDS), wherein a spectrum of major mutational targets associated with MDS, such as splicing factors and epigenetic regulators, has been revealed. The impact of mutations in these genes on disease subtypes and prognosis has also been evaluated. A mutation in SF3B1, one of the...
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