ZNF224 is a transcriptional repressor of AXL in chronic myeloid leukemia cells.

doi:10.1016/j.biochi.2018.08.011

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Article

ZNF224 is a transcriptional repressor of AXL in chronic myeloid leukemia cells.

Biochimie - 1 Nov 2018

Sodaro Gaetano, Blasio Giancarlo, Fiorentino Federica, Auberger Patrick, Costanzo Paola, Cesaro Elena

Abstract excerpt

ZNF224 is a KRAB-zinc finger transcription factor that exerts a key tumor suppressive role in chronic myelogenous leukemia. In this study, we identify the receptor tyrosine kinase Axl as a novel target of ZNF224 transcriptional repression activity. Axl overexpression is found in many types of cancer and is frequently associated with drug resistance. Interestingly, we also found that sensitivity to imatinib can be...

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Identifiers

PMID: 30176265
DOI: 10.1016/j.biochi.2018.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.