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Article

Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service.

Italian journal of pediatrics - 31 Aug 2018

Orsini A, Sammartino I, Valetto A, Bertini V, Marchese P, Bonuccelli A, Peroni D G

Abstract excerpt

BACKGROUND: In adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children. METHODS: A retrospective study of children referred with headache to a tertiary level Paediatric Neurology Service between 2008 and 2012. This study included only patients who had been genotyped for the MTHFR C677T polymorphism. An evaluation...

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Identifiers

PMID: 30170616
DOI: 10.1186/s13052-018-0546-1
PMCID: PMC6119283

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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