Article
A comprehensive evaluation of the genetic architecture of sudden cardiac arrest.
European heart journal - 21 Nov 2018
Ashar Foram N, Mitchell Rebecca N, Albert Christine M, Newton-Cheh Christopher, Brody Jennifer A, Müller-Nurasyid Martina, Moes Anna, Meitinger Thomas, Mak Angel, Huikuri Heikki, Junttila M Juhani, Goyette Philippe, Pulit Sara L, Pazoki Raha, Tanck Michael W, Blom Marieke T, Zhao XiaoQing, Havulinna Aki S, Jabbari Reza, Glinge Charlotte, Tragante Vinicius, Escher Stefan A, Chakravarti Aravinda, Ehret Georg, Coresh Josef, Li Man, Prineas Ronald J, Franco Oscar H, Kwok Pui-Yan, Lumley Thomas, Dumas Florence, McKnight Barbara, Rotter Jerome I, Lemaitre Rozenn N, Heckbert Susan R, O'Donnell Christopher J, Hwang Shih-Jen, Tardif Jean-Claude, VanDenburgh Martin, Uitterlinden André G, Hofman Albert, Stricker Bruno H C, de Bakker Paul I W, Franks Paul W, Jansson Jan-Hakan, Asselbergs Folkert W, Halushka Marc K, Maleszewski Joseph J, Tfelt-Hansen Jacob, Engstrøm Thomas, Salomaa Veikko, Virmani Renu, Kolodgie Frank, Wilde Arthur A M, Tan Hanno L, Bezzina Connie R, Eijgelsheim Mark, Rioux John D, Jouven Xavier, Kääb Stefan, Psaty Bruce M, Siscovick David S, Arking Dan E, Sotoodehnia Nona
Abstract excerpt
Aims: Sudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA. Methods and results: We carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also...
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