Article
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
Science (New York, N.Y.) - 31 Aug 2018
Anderson Nathaniel D, de Borja Richard, Young Matthew D, Fuligni Fabio, Rosic Andrej, Roberts Nicola D, Hajjar Simon, Layeghifard Mehdi, Novokmet Ana, Kowalski Paul E, Anaka Matthew, Davidson Scott, Zarrei Mehdi, Id Said Badr, Schreiner L Christine, Marchand Remi, Sitter Joseph, Gokgoz Nalan, Brunga Ledia, Graham Garrett T, Fullam Anthony, Pillay Nischalan, Toretsky Jeffrey A, Yoshida Akihiko, Shibata Tatsuhiro, Metzler Markus, Somers Gino R, Scherer Stephen W, Flanagan Adrienne M, Campbell Peter J, Schiffman Joshua D, Shago Mary, Alexandrov Ludmil B, Wunder Jay S, Andrulis Irene L, Malkin David, Behjati Sam, Shlien Adam
Abstract excerpt
Sarcomas are cancers of the bone and soft tissue often defined by gene fusions. Ewing sarcoma involves fusions between EWSR1, a gene encoding an RNA binding protein, and E26 transformation-specific (ETS) transcription factors. We explored how and when EWSR1-ETS fusions arise by studying the whole genomes of Ewing sarcomas. In 52 of 124 (42%) of tumors, the fusion gene arises by a sudden burst of complex,...
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