Article
CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Deniz Engin, Mis Emily K, Lane Maura, Khokha Mustafa K
Abstract excerpt
In the US and Europe, birth defects are the leading cause of infant mortality. Among birth defects, Congenital Heart Disease (CHD) occurs in approximately 8 out of 1000 live births, affects 1.3 million newborns per year worldwide, and has the highest mortality rate. While there is evidence to indicate that CHD does have a genetic basis, most of the CHD burden remains unexplained genetically. Fortunately, new...
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