Article
Misidentification of runs of homozygosity islands in cattle caused by interference with copy number variation or large intermarker distances.
Genetics, selection, evolution : GSE - 22 Aug 2018
Nandolo Wilson, Utsunomiya Yuri T, Mészáros Gábor, Wurzinger Maria, Khayadzadeh Negar, Torrecilha Rafaela B P, Mulindwa Henry A, Gondwe Timothy N, Waldmann Patrik, Ferenčaković Maja, Garcia José F, Rosen Benjamin D, Bickhart Derek, van Tassell Curt P, Curik Ino, Sölkner Johann
Abstract excerpt
BACKGROUND: Runs of homozygosity (ROH) islands are stretches of homozygous sequence in the genome of a large proportion of individuals in a population. Algorithms for the detection of ROH depend on the similarity of haplotypes. Coverage gaps and copy number variants (CNV) may result in incorrect identification of such similarity, leading to the detection of ROH islands where none exists. Misidentified hemizygous...
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