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Article

Role of retinal pigment epithelium‐derived exosomes and autophagy in new blood vessel formation

21 Aug 2018

Abstract excerpt

Autophagy and exosome secretion play important roles in a variety of physiological and disease states, including the development of age-related macular degeneration. Previous studies have demonstrated that these cellular mechanisms share common pathways of activation. Low oxidative damage in ARPE-19 cells, alters both autophagy and exosome biogenesis. Moreover, oxidative stress modifies the protein and genetic...

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PMID: 30133118
DOI: 10.1111/jcmm.13730

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