Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells.

doi:10.7554/eLife.33149

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells.

eLife - 22 Aug 2018

Del Mármol Josefina Inés, Touhara Kouki K, Croft Gist, MacKinnon Roderick

Abstract excerpt

Piezo1 is a mechanosensitive (MS) ion channel with characteristic fast-inactivation kinetics. We found a slowly-inactivating MS current in mouse embryonic stem (mES) cells and characterized it throughout their differentiation into motor-neurons to investigate its components. MS currents were large and slowly-inactivating in the stem-cell stage, and became smaller and faster-inactivating throughout the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Shape
Share to Gastrulation
Share to Ion Channel Gating
Share to Ion Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

Share to Motor Neurons

Share to Mouse Embryonic Stem Cells

Share to Pluripotent Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 30132757
DOI: 10.7554/eLife.33149
PMCID: PMC6128688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.