Article
UHPLC-MS/MS method for determination of atorvastatin calcium in human plasma: Application to a pharmacokinetic study based on healthy volunteers with specific genotype.
Journal of pharmaceutical and biomedical analysis - 25 Oct 2018
Xia Binbin, Li Yali, Zhang Yatong, Xue Ming, Li Xiaorong, Xu Pingxiang, Xia Tao, Chen Shicai
Abstract excerpt
A rapid, selective and sensitive ultra high performance liquid chromatography coupled with tandem triple quaternary mass spectrometry (UHPLC-MS/MS) method was developed and validated for the quantitative determination of atorvastatin calcium (AC) in human plasma. Separation of AC and rosuvastatin calcium (internal standard, IS) were achieved on a Dikma Leapsil C18 reversed phase column (100 × 2.1 mm, 2.7 μm) with...
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