Article
The fitness landscape of the codon space across environments.
Heredity - 1 Nov 2018
Fragata Inês, Matuszewski Sebastian, Schmitz Mark A, Bataillon Thomas, Jensen Jeffrey D, Bank Claudia
Abstract excerpt
Fitness landscapes map the relationship between genotypes and fitness. However, most fitness landscape studies ignore the genetic architecture imposed by the codon table and thereby neglect the potential role of synonymous mutations. To quantify the fitness effects of synonymous mutations and their potential impact on adaptation on a fitness landscape, we use a new software based on Bayesian Monte Carlo Markov...
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