Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway.

doi:10.1038/s41598-018-30530-6

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Article

Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway.

Scientific reports - 17 Aug 2018

Kim Jeong Eun, Hong Ji Won, Lee Hannah S, Kim Wankyu, Lim Jisun, Cho Yoon Shin, Kwon Ho Jeong

Abstract excerpt

Ubiquinol cytochrome c reductase binding protein (UQCRB) is known to play crucial roles in the development of various types of diseases. However, the link between UQCRB and microRNAs remains unknown. In the present study, we performed microRNA sequencing of mutant UQCRB-expressing stable cell lines that exhibited pro-oncogenic activities caused by expression of the mutant UQCRB gene. Results showed that...

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Identifiers

PMID: 30120311
DOI: 10.1038/s41598-018-30530-6
PMCID: PMC6098055

Genes

UQCRB
LSS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.