Retrospective evaluation of a decision-support algorithm (MIPOGG) for genetic referrals for children with neuroblastic tumors.

doi:10.1002/pbc.27390

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Article

Retrospective evaluation of a decision-support algorithm (MIPOGG) for genetic referrals for children with neuroblastic tumors.

Pediatric blood & cancer - 1 Dec 2018

Goudie Catherine, Cullinan Noelle, Villani Anita, Mathews Natalie, van Engelen Kalene, Malkin David, Irwin Meredith S, Foulkes William D

Abstract excerpt

BACKGROUND: Neuroblastoma is the most common pediatric extracranial solid tumor. Germline pathogenic variants in ALK and PHOX2B, as well as other cancer predisposition genes, are increasingly implicated in the pathogenesis of neuroblastic tumors. A challenge for clinicians is the identification of children with neuroblastoma who require genetics evaluation for underlying cancer predisposition syndromes (CPS)....

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PMID: 30117275
DOI: 10.1002/pbc.27390

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